Mindblown: a blog about philosophy.
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Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system
Animals Mice were purchased from the Jackson Lab with genotypes including C57BL/6 (JAX # 000664), Thy1-EGFP-M (JAX# 007788), Thy1-YFP-16 (JAX #003709), Ai14 (JAX# 007908), Ai 140 (JAX# 030220), Shh-CreERT2 (JAX# 005623) and Gli1-creERT2 (JAX# 007913). All animal experiments were approved by the Institutional Animal Care and Use Committee of the Chinese Institute for Brain Research. For…
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Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery
In this study, patients with negative (≥ 2 mm) and close (< 2 mm) margins showed similar local recurrence rates with boost dose-escalation according to margin width. However, radiation doses > 65 Gy EQD2 did not nullify the negative effect of positive margins on local control. In patients with high-grade DCIS, more widely clear margins were associated with lower recurrence…
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Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Huang, L. & Tepaamorndech, S. The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles. Mol. Asp. Med. 34, 548–560 (2013). Article CAS Google Scholar Kambe, T., Tsuji, T., Hashimoto, A. & Itsumura, N. The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and…
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Programmable synthetic receptors: the next-generation of cell and gene therapies
Naldini, L. Gene therapy returns to centre stage. Nature 526, 351–360 (2015). Article CAS PubMed Google Scholar Yamanaka, S. Pluripotent stem cell-based cell therapy—promise and challenges. Cell Stem Cell 27, 523–531 (2020). Article CAS PubMed Google Scholar Kimbrel, E. A. & Lanza, R. Next-generation stem cells — ushering in a new era of cell-based therapies.…
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First meteor shower of the year will peak this week
Stargazers will have quite a treat to look forward to this month as the first meteor shower of 2024, the Quadrantids, will peak on Thursday, January 4. The shower itself has been active since December 26, and it will continue to be visible in the night sky throughout January 16, 2024. However, the best time…
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We’ve Never Found Anything Like Our Solar System. Is It a Freak in Space? : ScienceAlert
Since the landmark discovery in 1992 of two planets orbiting a star outside of our Solar System, thousands of new worlds have been added to a rapidly growing list of ‘exoplanets’ in the Milky Way galaxy. We’ve learnt many things from this vast catalogue of alien worlds orbiting alien stars. But one small detail stands…
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There’s a Big Difference In How Your Brain Processes The Numbers 4 And 5 : ScienceAlert
Quick, how many apples are in the photo above? It’s easy to see there are three, but thanks to a distinct processing mechanism in your brain, it might have been even easier than you realize. According to a new study, the human brain has two separate ways of processing numbers of things: one system for…
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The Eternal Winter Island in Antarctica
Satellite image of Antarctica’s Argentine Islands captured on February 16, 2023, by the Operational Land Imager-2 on Landsat 9. The Antarctic island served as a winter base for early 20th-century polar explorers. Topped year-round with a layer of ice, Antarctica’s Argentine Islands display a winter-like appearance even in summer. Ice caps are visible across half of…
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Cummins To Pay Record $1.67B to Settle Claims of Bypassing Emissions Tests
Engine manufacturer Cummins, Inc., has agreed to pay $1.67 billion to the Justice Dept. to settle an investigation over potential violations of the Clean Air Act regarding devices that allow users to defeat emissions controls systems in Dodge Ram 2500 and 3500 engines. Continue Reading News Source: www.enr.com
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SpaceX’s first Falcon 9 launch of 2024 to feature first 6 direct-to-cell Starlink satellites – Spaceflight Now
A Falcon 9 rocket stands ready to support the Starlink 7-9 mission from Vandenberg Space Force Base. The mission also includes the first six satellites that will be used for the company’s direct-to-cell service. Image: SpaceX SpaceX is wasting no time in kicking off what it plans to be a historically busy year for orbital…
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