Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery

In this study, patients with negative (≥ 2 mm) and close (< 2 mm) margins showed similar local recurrence rates with boost dose-escalation according to margin width. However, radiation doses > 65 Gy EQD2 did not nullify the negative effect of positive margins on local control. In patients with high-grade DCIS, more widely clear margins were associated with lower recurrence rates compared to 2 mm margins, which were suggested as an appropriate width for DCIS. Margin width ≥ 6 mm could reduce the difference in local control between patients with high-grade and…