Category: 5. Biology
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A machine learning approach to seizure detection in a rat model of post-traumatic epilepsy
PPKS rats develop PTE following a moderate-to-severe TBI Following TBI (Fig. 1), rats were recorded on average a total of 138 h 13 min (range 118 h 56 min to 166 h 25 min). Spontaneous seizures were detected in 53.3% (16 of 30) of PPKS rats. Seizures were evidenced by rhythmic spikes on the electrographic recording and a clinical correlate of behavioral…
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Unveiling metabolic pathways involved in the extreme desiccation tolerance of an Atacama cyanobacterium
Gloeocapsopsis dulcis genome Genomic characteristics for G. dulcis are summarized in Table 1. Following sequence assembly in Trycycler13 we obtained a genome comprised of a ~ 5.29 Mbp chromosome and two plasmids, 11,484 and 307,228 bp in size. The mean read depth of the main chromosome was 492× as determined by Polypolish20. The mean read depth for the larger and…
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Boosted electrostatic biocatalysis
Boosted electrostatic biocatalysis Continue Reading News Source: www.nature.com
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A de novo evolved gene contributes to rice grain shape difference between indica and japonica
Genome-wide association study We carried out GWAS for grain shape using the panel of both indica and japonica varieties, which were obtained from the germplasm band or breeders in central China. We rephenotyped the grain shape-related traits, such as grain length (GL) and grain width (GW) of 289 rice varieties, including 158 japonica varieties genotyped…
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Species-specific responses of marine bacteria to environmental perturbation
Worden AZ, Follows MJ, Giovannoni SJ, Wilken S, Zimmerman AE, Keeling PJ. Rethinking the marine carbon cycle: Factoring in the multifarious lifestyles of microbes. Science. 2015;347:1257594–1257594. PubMed Google Scholar Moran MA. The global ocean microbiome. Science. 2015;350:aac8455–aac8455. PubMed Google Scholar Sunagawa S, Coelho LP, Chaffron S, Kultima JR, Labadie K, Salazar G, et al. Structure…
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BAP1 promotes osteoclast function by metabolic reprogramming
Reagents Recombinant murine M-CSF was obtained from R&D Systems (Minneapolis, MN). Glutathione S-transferase (GST)-RANKL was expressed in our laboratory as described52. The source of reagents is as follows: Mito Stress Kit, 2-deoxyglucose, glucose, glutamine, and Seahorse assay medium was purchased from Agilent Technologies. Mice All animals were housed in the animal care unit of Washington…
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Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
Structural approach to identify endogenous ligands of oGPCRs In addition to increasing cAMP levels, caoGPCRs recruit Gαs more efficiently than most other oGPCRs (Fig. 1a and Supplementary Table 1), as shown by NanoBiT mini-Gαs recruitment assay24. Moreover, they all contain a large hydrophobic residue (L, M, or F) at position 34.51 of the second intracellular loop (ICL2)…
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Telomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma
Gerecke, C. et al. The diagnosis and treatment of multiple myeloma. Dtsch. Arztebl. Int. 113, 470–476 (2016). PubMed PubMed Central Google Scholar Naymagon, L. & Abdul-Hay, M. Novel agents in the treatment of multiple myeloma: A review about the future. J. Hematol. Oncol. 9, 52 (2016). Article PubMed PubMed Central Google Scholar Aksenova, A. Y.…
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SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation
SENP6 is required for maintaining genomic stability SENP6 is critical for cell cycle progression and cell survival17,23,26. Moreover, the knockdown of SENP6 results in an increase in γH2AX foci and an overall increase in γH2AX levels, demonstrating that SENP6 is required for genome stability17,24,27. We confirmed a similar increase in the number of γH2AX foci…
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Morphological characterization of wild Prunus scoparia Spach accessions in 11 provinces of Iran
The accessions investigated showed significant differences based on the traits (ANOVA, P < 0.01). The majority of the characters (90 out of 100) exhibited a coefficient of variation (CV) of higher than 20.00%, indicating considerable variation among the accessions. The lowest CVs belonged to nut thickness (11.12%), sepal shape (14.43%), nut width (14.43%), current branch leaf apex…