A machine learning approach to seizure detection in a rat model of post-traumatic epilepsy

PPKS rats develop PTE following a moderate-to-severe TBI

Following TBI (Fig. 1), rats were recorded on average a total of 138 h 13 min (range 118 h 56 min to 166 h 25 min). Spontaneous seizures were detected in 53.3% (16 of 30) of PPKS rats. Seizures were evidenced by rhythmic spikes on the electrographic recording and a clinical correlate of behavioral arrest with subtle oral automatisms and chewing (Fig. 2A). Lack of responsivity to external stimulation (e.g., tapping on glass chamber) during the seizure was documented at least once in each animal demonstrating ictal…