SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

SENP6 is required for maintaining genomic stability

SENP6 is critical for cell cycle progression and cell survival^17,23,26. Moreover, the knockdown of SENP6 results in an increase in γH2AX foci and an overall increase in γH2AX levels, demonstrating that SENP6 is required for genome stability^17,24,27. We confirmed a similar increase in the number of γH2AX foci upon knockdown of SENP6, as well as the number of SUMO2/3 foci, as determined by immunofluorescence (Fig. 1a–c). This was reversed by treating with the SUMO-E1 inhibitor ML792²⁸, indicating that the DNA damage observed in the…