Category: 5. Biology
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ECOLE: Learning to call copy number variants on whole exome sequencing data
ECOLE overview Our model ECOLE is a deep neural network model which uses a variant of the transformer architecture20 at its core. The transformer is a parallelizable encoder-decoder model that receives an input and applies alternating layers of multi-headed self-attention, multi-layer perceptron (MLP), and layer normalization layers to it. Transformer architecture has achieved state-of-the-art results…
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Transcriptomic comparison between populations selected for higher and lower mobility in the red flour beetle Tribolium castaneum
Insects The red flour beetle, Tribolium castaneum (Herbst, 1797), is a stored-product insect found worldwide and a model species for genomics. The T. castaneum beetle culture used in this study has been maintained in the laboratory for more than 40 years22 according to the rearing method described by a previous study22. The T. castaneum population used…
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Author Correction: Bacterial pathogens deliver water- and solute-permeable channels to plant cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.…
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A retinotopic code structures the interaction between perception and memory systems
Libby, A. & Buschman, T. J. Rotational dynamics reduce interference between sensory and memory representations. Nat. Neurosci. 24, 715–726 (2021). Article CAS PubMed PubMed Central Google Scholar Kiyonaga, A., Scimeca, J. M., Bliss, D. P. & Whitney, D. Serial dependence across perception, attention, and memory. Trends Cogn. Sci. 21, 493 (2017). Article PubMed PubMed Central …
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CAR macrophages on a fast track to solid tumor therapy
CAR macrophages on a fast track to solid tumor therapy Continue Reading News Source: www.nature.com
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Translational enhancement of target endogenous mRNA in mammalian cells using programmable RNA-binding pentatricopeptide repeat proteins
Construction of designer PPR protein gene The designer PPR protein gene vector was constructed using the golden gate assembly method and PPR3.0 scaffold as described by Yagi et al29. Briefly, an intermediate plasmid containing two PPR motifs was chemically synthesized (Azenta Life Science, Chelmsford, MA, USA). The respective PPR scaffolds comprised 144 plasmids and were…
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Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling
Animal and animal care All mice procedures complied with the Institutional Animal Care and Use Committee guidelines of the School of Life Sciences, Westlake University (approval no. 20-033-JJM). NG2DsRedBac, Thy1-YFP-H, Ai14 (Gt(ROSA)26Sortm14(CAG-tdTomato)Hze) and Ai96 (Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze mice (The Jackson Laboratory, stock nos. 008241, 003782, 007914 and 024106, respectively) were kindly provided by the laboratory of W.-p.G.…
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LC–MS profiling, in vitro and in silico C-ABL kinase inhibitory approach to identify potential anticancer agents from Dalbergia sissoo leaves
Reynolds, R. et al. A systematic review of chronic disease management interventions in primary care. BMC Fam. Pract. 19, 1–13 (2018). Article Google Scholar Joyce Nirmala M., Samundeeswari A. & Deepa Sankar, P. Natural Plant Resources in Anti-Cancer Therapy—A Review. 01–14 Preprint (2011). Okouneva, T., Hill, B. T., Wilson, L. & Jordan, M. A. The…
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Fructose sweetens antitumor responses | Nature Immunology
Fructose consumption is associated with tumor growth and metastasis, but its role in the antitumor immune response is unclear. In Cell Metabolism, Zhang et al. find that dietary fructose shapes adipocyte metabolism, which enhances CD8+ T cell responses and controls tumor growth. When mice were maintained on a high-fructose diet and challenged with B16-F10 melanoma…
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Author Correction: LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.…