Mindblown: a blog about philosophy.
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CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer
Rb-loss in a mouse model of TNBC reduces hallmarks of immune response We previously demonstrated by Gene Set Enrichment Analysis (GSEA) that immune response pathways are downregulated in Rb:p53-deficient vs. p53-deficient murine models of TNBC [23]. To further probe the effect of Rb-loss on the immune microenvironment in these isogenic tumors, we analyzed the data…
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Boron nitride-enabled printing of a highly sensitive and flexible iontronic pressure sensing system for spatial mapping
Device fabrication and structural characterization Spatial mapping through flexible sensing arrays is an effective approach for health care monitoring and gesture recognition. However, manufacturing such flexible and wearable pads is difficult and expensive via conventional microelectromechanical system (MEMS) approaches. In particular, due to interferences from electrostatic charges from the human body, it is often difficult…
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The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders
Catani M, Dell’acqua F, Thiebaut de Schotten M. A revised limbic system model for memory, emotion and behaviour. Neurosci Biobehav Rev. 2013;37:1724–37. Article PubMed Google Scholar Aggleton JP, Pralus A, Nelson AJ, Hornberger M. Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit. Brain.…
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Single-material MoS2 thermoelectric junction enabled by substrate engineering
Chen, J. H. et al. Charged-impurity scattering in graphene. Nat. Phys. 4, 377–381 (2008). Article CAS Google Scholar Zhang, Y., Brar, V. W., Girit, C., Zettl, A. & Crommie, M. F. Origin of spatial charge inhomogeneity in graphene. Nat. Phys. 5, 722–726 (2009). Article CAS Google Scholar Wang, Q. H. et al. Understanding and controlling…
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Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters
Ancestral/Beta bivalent CoV2 preS dTM-AS03 confers more balanced and broader neutralizing antibody responses than D614 or Beta monovalent vaccines in naïve NHPs We first checked for potential immune interference between the two valences in the bivalent formulation as compared to the D614 or Beta monovalent formulations. Naïve cynomolgus macaques were immunized on D0 and D21 with…
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Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population
Individuals studied and demographics A total of 845 patients, comprising 529 pediatric and 316 prenatal probands, were enrolled (Table 1). The pediatric group included more males (290/529, 54.8%) than females (239/529, 45.2%), which was significantly different from a 50:50 distribution (χ2 = 4.92, P = 0.027). The prenatal group also included more male (171/316, 54.1%) than female fetuses (145/316,…
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Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Clinical specimens A total of 33 primary or recurrent LPS tumor tissue samples and 20 matched adjacent adipose tissue samples, were acquired from patients who underwent surgical resections from 1992 to 2019 at The Ohio State University Wexner Medical Center and included 18 of well-differentiated retroperitoneal LPS and 15 of dedifferentiated retroperitoneal LPS. Each case…
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Both reactive and proactive control are deficient in children with ADHD and predictive of clinical symptoms
Participants’ demographics One hundred and seven children (9–12 years old) were recruited from the local community. 50 children with ADHD (16F/34M, 11 ± 1 years old) and 30 TD children (14F/16M, 11 ± 1 years old) who completed two runs of SST and two runs of CSST and met task performance criteria (see the “Methods” section for details) were…
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Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection
This longitudinal antibody study with follow-up times up to 20 months provided the opportunity to understand long-term anti-SARS-CoV-2 antibody dynamics and to evaluate binding antibody levels from a commercial widely available immunoassay as a correlate of protection against infections during the Omicron BA.1/BA.2 era. Anti-S antibodies persisted up to 20 months after the probable date…
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