Author: appsfornexus
-
Perovskite photodetector-based single pixel color camera for artificial vision
In the past decade, there has been a fast development in single pixel imaging, a powerful technique emerging as a promising alternative to multipixel image sensors, such as the silicon focal plane arrays (FPAs) featuring millions of pixels. By using a single-pixel detector, in combination with different modulation technologies and sampling schemes, single-pixel imaging has…
-
Interoperable slide microscopy viewer and annotation tool for imaging data science and computational pathology
Slim is a web application that runs fully client side in modern web browsers and communicates with servers via standard DICOMweb services37 to query, retrieve, or store data (Fig. 1). By relying on the open DICOMweb API specification, Slim is independent of a particular server implementation and can interoperate with any server that exposes a DICOMweb…
-
Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease
dPerk expression results in intestinal dysfunction and decreased lifespan Pink1 mutant flies exhibit compromised mitochondrial function, characterised by loss of the mitochondrial membrane potential (Δψm) and activation of the kinase dPerk [9]. They also show intestinal dysfunction characterised by an increase in cell death in the midgut [11]. We first tested whether prolonged expression of…
-
Clinical evidence for immune-based strategies in early-line multiple myeloma: current challenges in decision-making for subsequent therapy
Brief overview of multiple myeloma Multiple myeloma (MM) is a cancer of the B-cell lineage resulting from the hyperproliferation of malignant plasma cells in the bone marrow, which is largely due to the dysregulation of oncogenic signaling pathways and abnormal immune function [1]. Most patients with MM experience relapse and eventually develop disease that is…
-
Viruses in sewage help to pinpoint typhoid hotspots
A man walks through stagnant water on ground floor of a primary school in Bangladesh.Credit: Zabed Hasnain Chowdhury/SOPA Images/LightRocket via Getty Scanning waste water for viruses that infect the bacterium that causes typhoid fever — rather than the bacterium itself — could inform vaccine roll-outs, according to two studies conducted in Bangladesh1 and Nepal2, which…
-
The long non-coding RNA PVT1 promotes tumorigenesis of cutaneous squamous cell carcinoma via interaction with 4EBP1
Cell culture The CSCC cell lines A431 and COLO16 and the human immortal keratinocyte line (HaCaT) were provided by the central laboratory of the Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College. The CSCC cell line, SCL-1, was purchased from the Cell Bank of the Shanghai Institute, Shanghai, China. Cells…
-
Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks
Cell lines and culture The human bladder cancer-derived cell lines RT112, 5637, KK47, and SCaBER were obtained from DSMZ (Heidelberg, Germany). MGH-U3, KK47 and SD48 cell lines were provided by Yves Fradet (CRC, Quebec), Jennifer Southgate laboratory (previously of Cancer Research Unit, St James’s University Hospital, Leeds, UK), and Henri Mondor Hospital (Créteil, France), respectively.…
-
Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis
Kras and p53 mutation are among the most common gene mutations in lung cancer, which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction, which has been implicated to promote the inflammation-to-cancer transition.2 We established a lung adenocarcinoma model by using conditional alleles of KrasLSL-G12D/p53flox/flox in mice3 to…
-
Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair
Glioblastoma (GBM) is one of the most fatal brain tumors. Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide (TMZ) chemotherapy show very limited efficacy.1,2 Novel therapeutic approaches for GBM patients are urgently needed. Natural products are important sources for drug discovery, especially in the field of cancer treatment.3 We previously isolated stellettin B…
-
New Study Shows That Artificial Intelligence Could Help Locate Life On Mars
Using AI To Find Life On Mars … Continue Reading News Source: astrobiology.com