Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis

Hypoxia was identified as a characteristic of AA

The reduction and visualization of transcriptome data from the exploration cohort, GSE28829, using the PCA algorithm showed significant heterogeneity between EA and AA (Fig. 2A). With a threshold of p < 0.05 and |log2FC|> 0.5, 625 highly elevated genes and 374 significantly downregulated genes were discovered in AA samples of the exploration cohort (Fig. 2B). The HIF-1 signaling pathway genes were then significantly enriched in the AA samples by GSEA analysis as shown in Fig. 2C (enrichment score = 0.4902, adjust p = 0.0277)….