Tissue-resident memory cells are key to immunity to Salmonella in mice

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease. New work from researchers at the UC Davis School of Veterinary Medicine shows how memory T cells, crucial for a vaccine that induces a powerful immune response, can be recruited into the liver in a mouse model of Salmonella.

The work was published April 11 in Proceedings of the National Academy of Sciences.

Understanding the immunology is key to developing a better vaccine.”

Professor Stephen…