A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease

Human cohorts

Health Retirement Study (HRS)

Participants

Data are from the Health and Retirement Study (HRS), a nationally representative sample of older Americans over age 50 [19, 20] in the contiguous United States. The present analysis was limited to participants who self-reported their race as white/Caucasian, verified by principal components analysis of ancestry markers, in order to assess effects of the SHLP2 minor allele only found in European ancestry groups. The analytical sample for the HRS included individuals who had available genetic data, at…