Integrated whole transcriptome profiling revealed a convoluted circular RNA-based competing endogenous RNAs regulatory network in colorectal cancer

In recent decades, considerable advancements in technology and clinical trials have significantly improved the detection, staging, and treatment of CRC. However, despite these developments, CRC remains one of the leading causes of cancer-related deaths worldwide^24,25. One of the significant reasons for its high mortality rate and poor overall survival is late detection⁵. While CRC survival rate are high when detected early (up to 90 percent five-year survival for early detection at stage 1), it significantly decreases for late diagnosis. As a result, researchers have made many attempts to…