Lactylation constrains OXPHOS under hypoxia

Cells sense and adapt to oxygen availability. A new study published in Cell Research reports that hypoxia-induced mitochondrial protein lactylation halts oxidative phosphorylation, underscoring the swift cellular response to low oxygen.

Hypoxia impacts diverse physiological processes, including cellular metabolism.¹ Cells respond to oxygen deficiency by suppressing mitochondrial oxidative phosphorylation (OXPHOS) to mitigate the generation of reactive oxygen species (ROS) and oxidative damage. This metabolic adaptation involves hypoxia-inducible factors (HIFs) that…