Using molecular ‘cookie cutters’ to view membrane protein organization

With Native-nanoBleach, nanodiscs containing target membrane proteins and their native cell membrane environment are cut out of the cell membrane. Each protein subunit has a molecule attached to it that fluoresces under light. Over time, the light exposure will bleach the fluorescent molecules, and the step-wise decrease in fluorescence allows researchers to count how many protein subunits are in each nanodisc. Credit: Moitrayee Bhattacharyya

The membrane that encases a biological cell is not…

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News Source: phys.org