High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

Comparing viral loads by treatment and VRC01 sensitivity of acquired viruses

To assess post-acquisition viral loads, we analyzed 608 viral load observations without ART from the 162 of 174 AMP participants who acquired HIV whose acquired viruses were tested for VRC01 neutralization sensitivity by the TZM-bl assay^34,35,36. Approximately 70% of participants had 3 or more viral loads preceding ART initiation, with 30% having more than 4 (Supplementary Table 1).

Across trials (HVTN 704/HPTN 085 and HVTN 703/HPTN 081), there were no obvious differences in viral load trajectories by treatment arm…