YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis

YAP silencing in SCLC is obligatory for tumor metastasis

YAP is a transcription co-activator in the Hippo signaling pathway and is often elevated in cancer. Through pan-cancer bioinformatics analysis, we found that YAP expression is strongly downregulated in RB1 mutant SCLC cell lines, but not non-small cell lung cancer cell lines (NSCLC) (Supplementary Fig. S1a, b). We performed lung cancer tumor samples with a YAP antibody and confirmed YAP downregulation in SCLC tumors but not in lung adenocarcinoma or squamous cancer samples (Fig. 1a). Notably, non-NE cells in SCLC samples are YAP…