Iron-sulfur (Fe-S) proteins, essential to all life forms, are difficult to synthesise due to the complicated molecular machinery involved and sensitivity of Fe-S clusters to oxygen. In a new study, a team of researchers devised an innovative protocol for synthesising mature Fe-S proteins, by bringing together a recombinant sulfur assimilation (SUF) system and an oxygen-scavenging system, thereby, paving the way for new technologies and a better understanding of the evolution of life.
Fe-S clusters, which are a part of Fe-S proteins, are found across all forms of life. They play a…
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