Mindblown: a blog about philosophy.
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Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies
Generation of a rapamycin-inducible expression system in an oncolytic vaccinia virus vector We designed a series of chemogenetic switches to enable temporal control of the expression of multiple therapeutic payloads. Vaccinia virus (VV) is a cytoplasmic virus and while is able to infect and replicate in mammalian cells, its transcriptional machinery and genomic structure is…
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Application of quality-by-design for adopting an environmentally green fluorogenic determination of benoxinate hydrochloride in eye drops and artificial aqueous humour
Design and strategy for assay development The proposed reaction mechanism shown in Scheme 1 illustrates how BEN-HCl reacts with the reagent via its primary aliphatic amino group, stimulating the reagent’s fluorescence35,36,37,38,39. The obtained fluorophore emits light at a specific wavelength of 483 nm after its excitation at 393 nm (Fig. 2). Scheme 1 The reported reaction mechanism of…
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Learning dispatching rules via novel genetic programming with feature selection in energy-aware dynamic job-shop scheduling
Liang, Y., Cai, W. & Ma, M. Carbon dioxide intensity and income level in the Chinese megacities’ residential building sector: Decomposition and decoupling analyses. Sci. Total Environ. 677, 315–327 (2019). ADS CAS PubMed Google Scholar Jin, M. et al. Impact of advanced manufacturing on sustainability: An overview of the special volume on advanced manufacturing for…
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Nutritional and immune-related indicators-based Nomogram for predicting overall survival of surgical oral tongue squamous cell carcinoma
Ng, J. H., Iyer, N. G., Tan, M. H. & Edgren, G. Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study. Head Neck. 39(2), 297–304 (2017). Article PubMed Google Scholar Zhang, L. W. et al. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005–2013. Cancer Epidemiol. 57, 120–126…
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Efficient utilization of red mud waste via stepwise leaching to obtain α-hematite and mesoporous γ-alumina
Mahinroosta, M., Karimi, Z. & Allahverdi, A. Recycling of red mud for value-added applications: A comprehensive review. Encycl. Renew. Sustain. Mater. https://doi.org/10.1016/B978-0-12-803581-8.11474-2 (2020). Article Google Scholar Li, Z., Gu, H., Hong, B., Wang, N. & Chen, M. An innovative process for dealkalization of red mud using leachate from Mn-containing waste. J. Environ. Chem. Eng. 10,…
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Correction: p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea
Correction: p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea Continue Reading News Source: www.nature.com
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Microbial growth and adhesion of Escherichia coli in elastomeric silicone foams with commonly used additives
Antibacterial effect on the growth medium This experiment shows how the different additives in the foam and the difference in base material affect bacterial growth in the inoculation suspension within 24 h at 25 °C. The resulting concentrations of E. coli in Luria-Bertani medium (LB broth) surrounding the test cubes are depicted in Fig. 1. As the…
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Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis
Hypoxia was identified as a characteristic of AA The reduction and visualization of transcriptome data from the exploration cohort, GSE28829, using the PCA algorithm showed significant heterogeneity between EA and AA (Fig. 2A). With a threshold of p < 0.05 and |log2FC|> 0.5, 625 highly elevated genes and 374 significantly downregulated genes were discovered in AA samples of the…
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