Cells play ‘molecular roulette’ to determine how body fights disease

Graphical abstract. Credit: Immunity (2022). DOI: 10.1016/j.immuni.2022.08.004 A new discovery about how cells make antibodies has revealed the surprisingly random way the body’s immune system defends against infection and disease. The WEHI-led study showed cells responsible for making antibody proteins use a randomization process to determine which type of antibody to make, behavior that scientists… Continue reading Cells play ‘molecular roulette’ to determine how body fights disease

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Gene mutations should be tested routinely for ovarian cancer, say scientists

Credit: Unsplash/CC0 Public Domain Scientists from The University of Manchester have shown that testing for two gene families linked to a lifetime epithelial ovarian cancer risk of between 5% and 20% has a much higher than expected detection rate. Routine testing for mutations in homologous recombination (HR) and mismatch repair (MMR) genes in women with… Continue reading Gene mutations should be tested routinely for ovarian cancer, say scientists

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Newly Approved ALS Drug Relyvrio To Face Its Next Challenge: Pricing And Reimbursement

This image provided by Amylyx Pharmaceuticals shows a box containing the drug Relyvrio. The … [+] much-debated drug for ALS or Lou Gehrig’s Disease won approval by the Food and Drug Administration on Thursday, Sept. 29, 2022. This represents a long-sought victory for ALS patients that is likely to renew questions about the scientific rigor… Continue reading Newly Approved ALS Drug Relyvrio To Face Its Next Challenge: Pricing And Reimbursement

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Scientists Identify Surprising Factors That Can Protect You Against Cognitive Decline

It is currently estimated that over 5 million individuals in the United States are affected by Alzheimer’s. Education, employment, and social life may all help protect the brain against cognitive decline. Why do some individuals with Alzheimer’s disease-related amyloid plaques in their brains exhibit no symptoms of the condition while others with the same amount of… Continue reading Scientists Identify Surprising Factors That Can Protect You Against Cognitive Decline

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Study finds the mechanism used by metastatic cancer cells to infiltrate the liver

The liver sinusoidal endothelial cells (LSECs, beige) surround a blood vessel containing a cancer cell (green). The cancer cell is able to induce the formation of intracellular gaps (iGaps, red), through inducing MMP9. Credit: Matsubara, Osaka Metropolitan University Metastasis—when cancer spreads to form new tumors—causes approximately 90% of cancer-related deaths. Because metastatic cancer cells circulate… Continue reading Study finds the mechanism used by metastatic cancer cells to infiltrate the liver

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Medical guidelines that embrace the humility of uncertainty could help doctors choose treatments with more research evidence behind them

Clinical guidelines greatly influence how doctors care for their patients. By providing recommendations on how to diagnose and treat particular situations, guidelines can help standardize the care patients receive. For instance, when a patient is suffering from an infection, a physician can consult the relevant guidelines to confirm that antibiotics are the appropriate treatment. Regulators,… Continue reading Medical guidelines that embrace the humility of uncertainty could help doctors choose treatments with more research evidence behind them

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Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

In a recent study posted to the bioRxiv* server, researchers performed a genomic study of confirmed Monkeypox virus (MPXV) cases diagnosed in Spain between 18 May and 14 July 2022. Study: Genomic accordions may hold the key to Monkeypox Clade IIb’s increased transmissibility. Image Credit: FOTOGRIN/Shutterstock Background In the current outbreak, the number of disseminated… Continue reading Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

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WHO warns Haiti cholera toll could rise

Scanning electron microscope image of Vibrio cholerae. Credit: Wikipedia Haiti’s cholera outbreak death toll is likely “much higher” than reported and expected to rise, the World Health Organization said Tuesday, warning the country’s multiple crises would complicate the humanitarian response. The crisis-wracked Caribbean nation said Sunday that at least seven people had died from cholera,… Continue reading WHO warns Haiti cholera toll could rise

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CDC Ends Country-By-Country Covid-19 Travel Health Advisories

The CDC’s move reflects an ongoing shift toward normalcy. getty In yet another sign that the world is moving past the Covid-19 pandemic, the Centers for Disease Control and Prevention (CDC) is no longer maintaining a country-by-country list of Covid-related travel advisories. From here on out, the CDC will only issue a travel health notice… Continue reading CDC Ends Country-By-Country Covid-19 Travel Health Advisories

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What are the challenges of COVID-19 vaccination and herd immunity?

A recent study published in The Clinical Respiratory Journal reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity. Study: Challenges of vaccination and herd immunity in COVID-19 and management strategies. Image Credit: Komsan Loonprom/Shutterstock Globally more than 6.5 million deaths have occurred due to COVID-19. Multiple COVID-19 outbreaks have been witnessed, primarily due… Continue reading What are the challenges of COVID-19 vaccination and herd immunity?

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