Cortex-wide topography of 1/f-exponent in Parkinson’s disease

Given chronic change in the neuromodulator dopamine, we expect that excitation and inhibition (EI) balance may be altered in the neocortical regions. To test this we analysed the aperiodic activity of MEG data which has been inversely related to EI balance in several previous studies20,21,22,23,24,25,26,27,28,29. We found that the 1/f-exponent (λ) was higher in PD patients than in HC in most brain regions but not in frontal regions. The most significant changes occurred within sensory and motor regions. Moreover, we found that λ showed a spatial gradient from posterior to anterior brain…

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