Deciphering progesterone’s mechanisms of action in breast cancer
An integrated representation of the multifaceted effects of progesterone in breast cancer. A schematic representation to describe the molecular mechanisms by which progesterone acts to curb cellular stress response and promote cell survival in breast cancer cells. Whole transcriptomic studies (represented by dotted lines) suggest that progesterone downregulates genes involved in the inflammatory response and TNF production while upregulating the central node ubiquitin gene UBC and N-myc downregulated gene 1, NDRG1, in…
