Clinicopathologic characteristics of second primary squamous cell carcinoma in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy

The Sun Yat-Sen University Cancer Center is the largest therapy and diagnosis center of NPC in southeastern China. According to the institutional electronic medical records, a total of 49,021 patients with NPC were treated by definitive RT in our Cancer Center between January 1970 and December 2009 and information about their pretreatment characteristics, therapy, and outcome is available. From this database we were able to identify 15 male patients for IMRT group who (1) had second primary squamous cell carcinoma (SPSCC) arising in the head and neck, (2) were treated only by IMRT for NPC,…