Host and in vitro genomic variability of SARS-CoV-2 and its variants

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the world over the last two years. With substantial human reservoirs with limited immunity, many new SARS-CoV-2 variants and sublineages of these variants have arisen.

Study: SARS-CoV-2 within-host and in-vitro genomic variability and sub-genomic RNA levels indicate differences in viral expression between clinical and in-vitro cohorts.

Even individuals who have contracted coronavirus disease 2019 (COVID-19) previously, or have been vaccinated, are still at risk, as reports of reinfections and vaccine breakthrough infections increase daily. SARS-CoV-2 strains such as the Delta and Beta variants show significant mutations in the spike protein that can help them evade immune…

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