Flu virus shells could improve delivery of mRNA into cells

Illustration of flu virus-mimicking nanoparticle entering and releasing mRNA into a host cell (top). A special protein on the nanoparticle’s surface triggers it to fuse with the endosomal membrane, allowing its mRNA cargo to safely escape into the host cell (bottom). Credit: Angewandte Chemie International Edition

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells. Their approach involves packing mRNA inside nanoparticles that mimic the flu virus—a naturally efficient vehicle for delivering genetic material such as RNA inside cells.

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News Source: https://phys.org/news/2021-11-flu-virus-shells-delivery-mrna.html