Gene mutations should be tested routinely for ovarian cancer, say scientists

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Scientists from The University of Manchester have shown that testing for two gene families linked to a lifetime epithelial ovarian cancer risk of between 5% and 20% has a much higher than expected detection rate.

Routine testing for mutations in homologous recombination (HR) and mismatch repair (MMR) genes in women with the disease who also have a family history of ovarian, breast and other cancers, would save lives, they say.

The study, published in the journal Genetics in Medicine, is the largest study of cancer causing genetic…

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