Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

In a recent study posted to the bioRxiv* server, researchers performed a genomic study of confirmed Monkeypox virus (MPXV) cases diagnosed in Spain between 18 May and 14 July 2022.

Study: Genomic accordions may hold the key to Monkeypox Clade IIb’s increased transmissibility. Image Credit: FOTOGRIN/Shutterstock


In the current outbreak, the number of disseminated MPXV transmission has remained consistently low, and it appears to transmit person-to-person (PTP) after a primarily localized rash appears. If the latter mode is responsible for MPXV transmission, it should also reflect at the genomic level. So far, all genomics studies have focused on describing MPXV’s evolutionary history and tracking its introduction to the virus in Western countries.


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