CBCT-based synthetic CT generated using CycleGAN with HU correction for adaptive radiotherapy of nasopharyngeal carcinoma

Image acquisition and processing

52 NPC patients receiving radiotherapy in Fujian Cancer Hospital from 2020 to 2021 were included in this study. This study has been approved by the ethics committee of Fujian Cancer Hospital (ethics number: SQ2020-043-01) and all patients provided written informed consent prior to enrollment in the study. All methods were performed in accordance with the Declaration of Helsinki as well as relevant guidelines and regulations. During simulation for treatment planning, CT images were obtained on a Brilliance CT Big Bore (Philips Medical Systems Inc., Cleveland,…