An assessment of potential epitopes in SARS-CoV-2 structural proteins

The coronavirus disease 2019 (COVID-19) is a highly contagious acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Phylogenetic analysis of SARS-CoV-2 whole-genome sequences isolated from infected patients revealed 96.2%, 79.6%, and 50% sequence identity with the genomes of RaTG13, SARS-CoV BJ01, and the Middle East respiratory syndrome coronavirus (MERS-CoV), respectively.

SARS-CoV-2 has a genome that encodes both structural and non-structural proteins (NSPs). Except for gamma coronavirus, which lacks NSP1, the initial open reading frame (ORF1a/b) encodes 16 NSPs (NSP1-16).

Study: Immunoinformatics mapping of potential epitopes in SARS-CoV-2 structural proteins. Image Credit: Design_Cells /…

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