For the first time, DNA and proteins sensed by de novo-designed nanopore

De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide. Credit: Ryuji Kawano, Tokyo University of Agriculture and Technology

Researchers in Japan have designed the first bottom-up designed peptides, comprising chains of amino acids, that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane.

Biological nanopores are generally channels made by…

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