Bacteriophages named after Norfolk village of Colney could help combat C. difficile infections

Viruses have a menacing reputation for causing disease but some that target bacteria could actually benefit human health.

These are called bacteriophages, and a group of them named after the Norfolk village of Colney could help combat C. difficile infections.

Clostridioides difficile, also known as C. diff, is a species of bacteria that infects the human gut. It can become a major problem when our normal gut microbes are impaired, most commonly during a course of antibiotics. This leads to an overgrowth of C. difficile, with toxins it produces causing diarrhoea and severe inflammation.

Treatment involves further courses of antibiotics, but relapse and recurrent infections are common. The strains are becoming more resistant to antibiotics and more capable of causing…

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