Study reveals how certain cells drive immunotherapy resistance in ovarian cancer mouse model

Immune checkpoint inhibitors are a type of cancer treatment that help the immune system’s T cells recognize and attack tumors. But these immunotherapy drugs aren’t effective against all cancers. In a study published today in Science Advances, University of Pittsburgh and UPMC researchers reveal how certain cells drive immunotherapy resistance in a mouse model of ovarian cancer and show that targeting a signaling pathway in these cells improved tumor responses to immunotherapy.

Senior author Ronald Buckanovich, M.D., Ph.D., professor of medicine at Pitt and co-director of the Women’s Cancer Research Center -; a collaboration between UPMC Hillman Cancer Center and Magee-Womens Research Institute -; discusses the significance of these findings and outlines how this research…

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