KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors

Ethics

All experimental procedures were approved by the Animal Care and Ethical Committee of Medical Research Institute, Wuhan University. Informed consent was obtained from all participants of the study.

Mice

Wild-type CD-1 (ICR) and C57BL/6 mice were obtained from the Hunan SJA Laboratory Animal Company (Changsha, China). Mice were housed in a certified specific-pathogen-free (SPF) facility. The noon of the day when the vaginal plug was found was counted as embryo (E) day 0.5.

Mouse lines used in this study included: Kdm2b^fl/fl (generated by Applied Stem Cell), Emx1-Cre (Jackson…