BHLHE40, a potential immune therapy target, regulated by FGD5-AS1/miR-15a-5p in pancreatic cancer

Landscape of BHLHE40 expression in pan-cancer and BHLHE40 is a significant prognostic predictor in pancreatic cancer

To investigate the expression of BHLHE40 in pan-cancer, we used TCGA and GTEX database including tumor tissues and normal tissues from 33 types of cancer to reveal that BHLHE40 were highly expressed in 7 of 33 tumor tissues compared to para-cancer tissues and were downregulated in 13 of 33 cancers (Fig. 1A). Further, Kaplan–Meier survival curves and log-rank test of these 20 types of cancers were assessed to identify that higher expression of BHLHE40 were correlated with…